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KMID : 0379120160440040314
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Korean Journal of Mycology
2016 Volume.44 No. 4 p.314 ~ p.317
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Screening of Potent Anti-dementia Acetylcholinesterase Inhibitor-containing Edible Mushroom Pholiota adiposa and the Optimal Extraction Conditions for the Acetylcholinesterase Inhibitor
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Kim Do-Yeon
Bae Sang-Min
Han Sang-Min
Lee Jong-Soo
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Abstract
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To develop a new anti-dementia acetylcholinesterase (AChE) inhibitor from edible mushrooms, AChE inhibitor activities were determined on water and ethanol extracts of various edible mushrooms from oriental medicine markets an agriculture markets. As a result, the 70% ethanol extract from fruiting body had the highest AChE inhibitor activity of 30.6, and its water extract also had an AChE inhibitory activity of 23.8%. Therefore, we finally selected as potent anti-dementia AChE inhibitor-containing mushroom. The AChE inhibitor of P. a d i p o s a was maximally extracted when i fruiting body was treated with water for 3hr at 70 C and 70% ethanol for 12 hr at 70 C, respectively.
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KEYWORD
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Acetylcholinesterase Inhibitor, Anti-dementia, Ethanol extract, Pholiota adiposa
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